Histopathological overdiagnosis in nephrology and urology: review from Russia

What is it about?

https://www.pubtexto.com/journals/journal-of-medical-and-clinical-studies/fulltext/histopathological-overdiagnosis-in-nephrology-and-urology-review-from-russia

Featured Image

Why is it important?

Renal biopsy is a valuable diagnostic tool. This review the renal biopsies used in Russia in research and practice with special reference to overdiagnosis and overtreatment. Among others the role biopsy in the following conditions is analyzed: glomerulo-and pyelonephritis, renovascular hypertension, alcoholism, diabetes mellitus and urinary tract malformations in children. The specimens used in certain studies have been unique e.g. wedge and core biopsies in hydronephrosis, acute and chronic pyelonephritis. The collection of specimens was associated with the risk, in particular, intra-operative excisions in acute pyelonephritis and hydronephrosis as well as pancreas biopsies. Morphological overdiagnosis of glomerulonephritis resulted in the overtreatment with steroids and cytostatica. A conclusion is that, considering possible adverse effects, renal biopsy for research should not exist as such; it must always be performed according to clinical indications. If a patient gives informed consent to research the tissue obtained for diagnostic purposes, it can be done, provided that enough material remains for the diagnostics. Quality of specimens and special methods (silver stain, electron microscopy) are of great importance when indicated. Besides, bladder biopsies and overdiagnosis of premalignant, in situ and microinvasive urothelial lesions are discussed in this review. More detail are in the book: https://www.cambridgescholars.com/product/978-1-0364-1329-3