What is it about?
This work demonstrates that insulin increases the glucose uptake rate in insulin sensitive cells by increasing the activity of transport proteins already in the membrane. The stimulation process is rapid, and when insulin is cleared, uptake returns quickly to basal rates again. The process occurs regularly throughout the day in man subsequent to ingestion of calories which stimulate insulin release into the bloodstream. . The process does not recruit or cause new transport proteins to be inserted into the bilayer which is an energy-consuming process. Insulin serves as the only hormone to conserve energy by increasing storage of fat and glycogen while inhibiting protein breakdown.
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Why is it important?
The effects of insulin on sensitive cells including muscle and fat need to be understood well, in order to properly correct type II diabetes and to perfect treatment of type I diabetes with proper insulinlzation management.
Perspectives
My diabetes research career with the National Institutes of Health was cut short because our experimental findings. We demonstrated that insulin stimulates glucose transport proteins already in the surface membrane of the cell rapidly, rather than causing additional proteins to be inserted into the membrane and removed again after the stimulation ends. Whether this involves changes in protein conformation that open additional pores or rather shortens the intramembrane path glucose takes to enter the cell is not yet known. This work is important to disseminate. since what is widely argued is the transporter insertion view, which is not conducive to frequent insulin releases multiple times daily that lead to rapid increases and rapid decreases in glucose uptake..
Dr. Richard Sauerheber
Palomar Community College
Read the Original
This page is a summary of: Perspectives on Insulin Stimulation of Glucose Transport, American Journal of Biomedical Science & Research, August 2019, BiomedGrid LLC,
DOI: 10.34297/ajbsr.2019.04.000834.
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