ANCA Kidney Risk Score (AKRiS) performance in a German Cohort of Patients with Histologically Confirmed ANCA-Associated Renal Vasculitis

What is it about?

Predicting the Course of ANCA-Associated Vasculitis (AAV)_x000D_ _x000D_ ANCA-associated vasculitis (AAV) is a serious condition that damages blood vessels. Predicting the course of the disease is challenging. A promising predictor is the ANCA Renal Risk Score (ARRS). This score has recently been updated and renamed the ANCA Kidney Risk Score (AKRiS)._x000D_ _x000D_ Researchers evaluated the AKRiS in a study of 164 patients with AAV. The patients had a more severe disease course than the patients enrolled in the ARRS development study._x000D_ _x000D_ The study results showed that the AKRiS also performed well in this population. It predicted the risk of kidney failure. Additionally, researchers identified new associations between risk categories of the AKRiS and disease progression or treatment outcome._x000D_ _x000D_ For example, anemia was associated with an increased risk of kidney failure, but C-reactive protein and the Birmingham Vasculitis Activity Score (BVAS) were not. Patients with a higher AKRiS risk had an increased risk of death, while patients with a lower ARRS risk had an increased risk of disease relapse._x000D_ _x000D_ The study findings show that the AKRiS is a valuable tool for predicting the course of AAV. It can help identify patients with a high risk of severe complications and recommend targeted treatment._x000D_ _x000D_ Conclusion:_x000D_ The AKRiS is a valid predictor for AAV, even in a population with a severe disease course. The study findings emphasize the potential of risk scores to predict the course of AAV._x000D_ _x000D_ _x000D_

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