Sex Differences in Cardiovascular and All-Cause Mortality in Adults with and without CKD: NHANES 1999–2018

What is it about?

Patients with chronic kidney disease (CKD) have a high risk of heart disease and are more likely to die of heart disease than to progress to end-stage kidney disease. Although it is important to address sex differences in kidney disease-related complications, sex differences in heart disease risk in the kidney disease population are understudied. We examined sex differences in the risk of heart disease-related death and all-cause death in adults with CKD who participated in the National Health and Nutrition Examination Survey (NHANES), a nationally representative data of community-dwelling U.S. adults. We found that women with CKD had a lower risk of heart disease-related death than men. Kidney function markers, such as estimated glomerular filtration rate and urinary albumin-to-creatinine ratio, may influence the risk of death in women with CKD, but not in men.

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