Influenza vaccine serology

What is it about?

This review compares and contrasts the different serological assays that are used for evaluating the immunogenicity of influenza vaccines. It covers the regulator-approved assays HI and SRH all the way through to neuraminidase assays and influenza pseudotype neutralization assays.

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Why is it important?

This review article highlights the growing importance of using influenza pseudotypes for vaccine immunogenicity studies. Pseudotypes are attractive for this as they efficiently measure both anti-head and anti-stalk HA responses, are amenable to high-throughput platforms and may be easier to standardise than HI as do not rely on erythrocytes.