Random lasing detection of mutant Huntingtin expression in cells

What is it about?

Huntington's disease (HD) is a devastating neurodegenerative condition caused by a genetic mutation in the huntingtin gene. This mutation leads to abnormal folding and clumping of the huntingtin protein cells, affecting their function and structure. We suggest using a technique called random lasing (RL) to detect the expression of this abnormal gene. By studying cells expressing different forms of the mutated gene, we found that RL signals differ significantly between healthy and mutated cells. Using advanced statistical methods, we identified distinct patterns in RL signals that could help diagnose HD.

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Photo by National Cancer Institute on Unsplash

Photo by National Cancer Institute on Unsplash

Why is it important?

Althought Huntington's disease is easily detected through genetic testing, there are not accesible biomarkers to track the onset of the disease before clinical symptoms arise, to track its evolution, and the effectiveness of applied treatments. This non-invasive approach holds promise for early detection and better understanding of HD, bringing us closer to effective treatments.