What is it about?
Influenza A viruses cause epidemics and pandemics with high mortality rates. Vaccines are available today, but they must be periodically reformulated due to the genetic variability of influenza viruses. Focusing on cellular targets co-opted by influenza viruses may be useful for the development of innovative antiviral drugs and broad-spectrum vaccines. This review highlights that highly pathogenic avian influenza A strains subvert the structure and function of the cellular cytoskeleton. The data available so far attest that this line of research must be pursued.
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Why is it important?
The use of the cellular cytoskeleton by highly pathogenic avian influenza A viruses represents an important step in their adaptation to mammals and, hence, to humans.
Perspectives
This review represents an update on the data available so far and a prerequisite for the realization of new scientific studies that, at the moment, are limited, given the high level of biosafety required.
Prof. Flora De Conto
Universita degli Studi di Parma
Read the Original
This page is a summary of: Avian Influenza A Viruses Modulate the Cellular Cytoskeleton during Infection of Mammalian Hosts, Pathogens, March 2024, MDPI AG,
DOI: 10.3390/pathogens13030249.
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