sensor for the detection for the detection of non-steroidal anti-inflammatory drugs

What is it about?

Electroanalytical techniques play a crucial role in various important fields, including medicine, clinical analysis, pharmaceutical research, and environmental cleanup. Among these techniques, voltammetric methods that use modified electrodes with nanomaterials have gained significant attention. In our study, we employed cadmium sulfide and zinc oxide nanoparticles as modifiers for electrodes to detect two non-steroidal anti-inflammatory drugs (NSAIDs), naproxen and mobic. The glassy carbon electrode modified with CdS showed a fourfold increase in the electro-oxidation signals of naproxen compared to the unmodified electrode, while the ZnO-modified electrode resulted in a twofold increase for mobic. The oxidation processes for both NSAIDs were influenced by pH, indicating that protons play a role in their electron transfer reactions. We optimized the experimental conditions to maximize the current response for these analytes.

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Why is it important?

It is important for getting insights about the role of sensors in probing the redox behavior of NSAIDs in biological systems and to monitor their metabolites in human serum and urine, which is essential for clinical diagnostics and understanding drug mechanisms.