What is it about?
During exercise, a hormone released that protect the brain against Alzheimer’s disease (AD). It also explains the positive effects of exercise on the brain. Hippocampus (plays a major role in learning and memory) is the most susceptible to AD. Interestingly, irisin particularly is capable of protecting the hippocampus. Herein, we describe the physiology of irisin and its potential role in delaying or preventing AD progression in humans.
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Why is it important?
A group of people who are unable to exercise regularly but have dementia or are at high risk of dementia could in the future to be given drugs to target irisin. Drugs designed to target the hormone could potentially bring some of the benefits of physical exercise to people who may be less able to exercise.
Perspectives
Exercise can improve longevity. However, we human being are too busy and love to spend time on social networking, thus we have not enough time to do physical exercise. This physical inactivity leads to various types of diseases. Therefore, irisin would be a future medicine to people who may be less able to exercise.
Dewan Md. Sumsuzzman
Inje University
Read the Original
This page is a summary of: Molecular and Functional Interaction of the Myokine Irisin with Physical Exercise and Alzheimer’s Disease, Molecules, December 2018, MDPI AG,
DOI: 10.3390/molecules23123229.
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