What is it about?
We found that all characterized human G-quadruplex binding proteins share a 20 amino acid long motif.
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Why is it important?
We have predicted a new set of potential G-quadruplex binding proteins in human.
Perspectives
We expect that our findings will contribute to the identification and characterization of G-quadruplex binding proteins, and to the development of tools for the optimization of proteins, peptides, or other small molecules that bind to these structures for potential clinical application.
Martin Bartas
Ostravska Univerzita v Ostrave
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This page is a summary of: The Amino Acid Composition of Quadruplex Binding Proteins Reveals a Shared Motif and Predicts New Potential Quadruplex Interactors, Molecules, September 2018, MDPI AG,
DOI: 10.3390/molecules23092341.
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