What is it about?
The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements to basic laws. In this work, a common framework for the Long COVID pathophysiological mechanism is presented, based on the blood supply deprivation and the flow diffusion equation.
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Why is it important?
Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary density reduction (CDR), and percentage of perfused vessel reduction (PPVR). The estimated tissue blood supply reduction (SR) for multiple tissues with data from 634 post-COVID patients reached a sizeable 47%. This large SR creates conditions of lower mass diffusion rates, hypoxia, and undernutrition, which, at a multi-tissue level, for a long time, can explain the wide variety of Long COVID symptoms.
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This page is a summary of: A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID, Life, August 2024, MDPI AG,
DOI: 10.3390/life14091076.
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