What is it about?
Like Saccharomyces cerevisiae, pathogenic fungi undergoes asymmetric cell division, which causes phenotypic variations between the mother and the daughter cells resulting in replicative aging. These variations include increased antifungal tolerance and virulence in the mother cells when compared to the daughter cells. This review article summarizes the different known techniques in studying replicative aging.
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Why is it important?
The review summarizes all the important techniques of studying replicative aging. It also explains the advantages and limitations of each techniques.
Perspectives
This article may draw interests in studying replicative aging in pathogenic fungi. Previously, most studies in aging where performed in non-pathogenic yeast. Studying in pathogenic yeast is highly important since aging results in increased virulence and drug tolerance in generationally old mother cells.
Dr Somanon Bhattacharya
SUNY Stony Brook
Read the Original
This page is a summary of: Replicative Aging in Pathogenic Fungi, Journal of Fungi, December 2020, MDPI AG,
DOI: 10.3390/jof7010006.
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