What is it about?
In this study, we found that persons affected by both diabetes and hidradenitis suppurativa (acne inversa), two common comorbidities, are faced with low insulin sensitivity (SPINA-GR). However, insulin resistance is not counteracted by dynamic compensation via increased pancreatic beta-cell function (SPINA-GBeta). As a consequence, the static disposition index of the feedback loop (SPINA-DI) is reduced, directly leading to impaired insulin-glucose homeostasis and paving the way to diabetes. A key mediator of this link may be found in inflammation. In the investigated population, there was a significant association between haptoglobin concentration as a biomarker for inflammation and SPINA-DI.
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Why is it important?
Diabetes mellitus is a common complication and comorbidity of hidradenitis suppurativa (also known as acne inversa). It may be both a consequence and a cause of the skin disease, and the two conditions aggravate each other. However, the mechanisms linking the two diseases are not well understood. More research on the mechanisms of this association is therefore highly needed.
Perspectives
The results of this research may suggest ways to improve metabolic comorbidities in chronic skin diseases. By demonstrating a strong link between inflammation and insulin resistance on the one hand and relative dysfunction of the pancreatic beta cells on the other hand, it points to potential novel treatment modalities.
apl. Prof. Dr. med. Johannes W Dietrich
Ruhr-Universitat Bochum
Read the Original
This page is a summary of: Endotyping Insulin–Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of Diabetes Mellitus and Inflammation, Journal of Clinical Medicine, March 2025, MDPI AG,
DOI: 10.3390/jcm14072145.
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