Role of Nutrition, Inflammation and Epigenetic in Cancer

What is it about?

Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.

Featured Image

Photo by National Cancer Institute on Unsplash

Photo by National Cancer Institute on Unsplash

Why is it important?

Tumor development is a complex process that is influenced by multiple factors beyond just alterations in oncogenes and tumor suppressor genes. The immunosuppressive tumor microenvironment, inflammatory state, and epigenetic reprogramming each play critical roles in this process, and are interconnected. Nutrition can significantly impact the regulation of these factors, making it an important tool in the prevention and treatment of neoplasms.