What is it about?
We presented a concise summary regarding how mitochondrial dysfunction affects the pathogenesis and progression of common oral inflammatory diseases such as periodontitis and pulpitis as well as the related systemic diseases. In addition, we also introduced several therapeutic strategies targeting mitochondrial dysfunction in those diseases.
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Why is it important?
Oral inflammatory diseases such as periodontitis and pulpitis are difficult to treat clinically at present. Such diseases not only affect people's oral health but also increase the risk of many systemic diseases. We summarized the recent studies on how mitochondrial dysfunction affects the pathogenesis and development of these diseases. We hope that targeting mitochondria dysfunction may serve as an effective approach to treat those diseases in the future.
Perspectives
Mitochondria dysfunction is present in all common oral inflammatory diseases mentioned above. When treating those diseases, in addition to remove the external stimuli of the diseases, addressing mitochondrial dysfunction is crucial for quick repair of damaged tissue and alleviation of clinical symptoms. Mitochondria-related indicators have the potential to assist the early diagnosis and prognosis evaluation of such diseases. We believe that mitochondria-targeted therapy is a promising therapeutic strategy in treating oral inflammatory diseases in the future.
Zhili Dong
Sun Yat-Sen University
Read the Original
This page is a summary of: Mitochondrial Dysfunction in the Pathogenesis and Treatment of Oral Inflammatory Diseases, International Journal of Molecular Sciences, October 2023, MDPI AG,
DOI: 10.3390/ijms242015483.
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