What is it about?
We developed an organotypic culture of substantia nigra as a model of Parkinson's disease. The cultures were treated with a low dose of rotenone and the neuronal degeneration was followed for 96 hours, analyzing the pathological process involved.
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Why is it important?
We create a new model to analyze the molecular events involved in the development of the disease and to test neuroprotective drugs.
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This page is a summary of: Earliest Mechanisms of Dopaminergic Neurons Sufferance in a Novel Slow Progressing Ex Vivo Model of Parkinson Disease in Rat Organotypic Cultures of Substantia Nigra, International Journal of Molecular Sciences, May 2019, MDPI AG,
DOI: 10.3390/ijms20092224.
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