What is it about?
Several studies, carried out both in vitro and in vivo, have suggested that the production of reactive oxygen species (ROS) is the main marker of cytotoxicity of TiO2 nanoparticles. By modifying the pH values during the synthesis, the physico-chemical properties as well as the photocatalytic behavior of the nanopowders, were obviously changed. Therefore, we used two types of Fe-N doped TiO2 nanoparticles obtained at two different pH values (8.5 and 5.5). Our results showed that lung fibroblasts are more susceptible to ROS attacks and nanoparticles synthesized under alkaline conditions have exerted a more pronounced cytotoxic effect both in skin and lung cells.
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Why is it important?
The present study is a highly complex research that compares the enzymatic and non-enzymatic mechanisms of lung and skin cells defense against oxidative stress induced by TiO2 NPs with extended photocatalytic properties in visible light.
Perspectives
I hope this article will have a great impact in the photocatalysis field and will make others realize the importance of biochemical studies in the development of new nanomaterials with improved photocatalytic properties.
Cristina Nica
Read the Original
This page is a summary of: Interaction of New-Developed TiO2-Based Photocatalytic Nanoparticles with Pathogenic Microorganisms and Human Dermal and Pulmonary Fibroblasts, International Journal of Molecular Sciences, January 2017, MDPI AG,
DOI: 10.3390/ijms18020249.
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