Monitoring the Response of Hyperbilirubinemia in the Mouse Brain by In Vivo Bioluminescence Imaging

What is it about?

Increased levels of unconjugated bilirubin are neurotoxic, but the mechanism leading to neurological damage has not been completely elucidated. In this study authors assessed the brain response to hyperbilirubinemia in vivo by non-invasive bioluminescence imaging into a mouse model in which light emission is restricted to the regions of active cell proliferation. Acute hyperbilirubinemia increased brain bioluminescence, indicating elevated cell proliferation. This increase was reversed by treatment with minocycline (an antibiotic with anti-inflammatory and neuroprotective properties) or bevacizumab (an anti-VEGF antibody).

Featured Image

Photo by Natasha Connell on Unsplash

Photo by Natasha Connell on Unsplash