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Severe hypoxic stress at the administration site is a major barrier to successful cell transplantation. This study tested whether making cells more resistant to low oxygen (hypoxia) could improve the regenerative potential of cell therapies. The authors engineered adipose-derived stromal cells to overexpress human manganese superoxide dismutase (MnSOD), a key antioxidant enzyme in the mitochondria. This modification protected the cells from hypoxia-induced death and significantly improved their survival after implantation.
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This page is a summary of: Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase, International Journal of Molecular Sciences, July 2016, MDPI AG,
DOI: 10.3390/ijms17071082.
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Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase
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Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase
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Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Int J Mol Sci (2017); 18(10):2087. doi: 10.3390/ijms18102087.
PubMed Central
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International Journal of Molecular Sciences Special Issue
Advances in Cell Transplantation
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