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This study evaluated the hypothesis that gene-mediated hypoxia resistance enhances the regenerative potential of cell therapies. By overexpressing human manganese superoxide dismutase in adipose-derived stromal cells, the authors achieved a significant cytoprotective effect that mitigated hypoxia-induced death and significantly increased graft survival rates post-implantation.
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This page is a summary of: Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase, International Journal of Molecular Sciences, July 2016, MDPI AG,
DOI: 10.3390/ijms17071082.
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Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase
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Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase
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Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Int J Mol Sci (2017); 18(10):2087. doi: 10.3390/ijms18102087.
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International Journal of Molecular Sciences Special Issue
Advances in Cell Transplantation
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