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Authors evaluated the hypothesis that overexpression of a gene conferring hypoxia resistance to cells before transplant could enhance survival of grafted cells in early stages after implant, therefore enhancing cell therapy regenerative potential. In particular, the study elucidated that gene transfer of human manganese superoxide dismutase into adipose tissue-derived stromal cells before implantation confers a cytoprotective effect leading to improved survival to hypoxia and increased engraftment rates.
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This page is a summary of: Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase, International Journal of Molecular Sciences, July 2016, MDPI AG,
DOI: 10.3390/ijms17071082.
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Promotion of Survival and Engraftment of Transplanted Adipose Tissue-Derived Stromal and Vascular Cells by Overexpression of Manganese Superoxide Dismutase
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Promotion of survival and engraftment of transplanted adipose tissue-derived stromal and vascular cells by overexpression of manganese superoxide dismutase
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Challenges and Strategies for Improving the Regenerative Effects of Mesenchymal Stromal Cell-Based Therapies
Int J Mol Sci (2017); 18(10):2087. doi: 10.3390/ijms18102087.
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International Journal of Molecular Sciences Special Issue
Advances in Cell Transplantation
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