What is it about?
Endometriosis and migraine are two complex disorders with increasing global public health importance. Observational studies have shown that the two disorders may co-occur, however, evidence conflicts and the mechanisms of their association are unknown. The present study performed a comprehensive assessment of the relationship between the two disorders by analysing genome-wide association studies (GWAS) genotype data. Findings indicate that endometriosis and migraine are indeed co-morbid with evidence showing that they share similar genetic etiology. We found genes shared by both endometriosis and migraine and identified biological pathways that potentially underlie both of them.
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Why is it important?
Endometriosis affects as much as 10% of women of reproductive age, worldwide. Migraine, similarly has a global prevalence of up to 15% among women. The cause of the two disorders are currently unknown just as there are no assurance of a curative treatment for them. Our study using statistical genetic approach identified genes and biological pathways that improve our understanding of the biological mechanisms of endometriosis and migraine and which may serve as potential therapeutic targets for both of them.
Perspectives
Our study provides strong evidence for the co-occurrence of endometriosis and migraine, as well as identified genes and pathways shared by the two disorders. The identified genes and pathways could serve as plausible therapeutic targets for the disorders.
Emmanuel O Adewuyi
Queensland University of Technology
Read the Original
This page is a summary of: Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity, Genes, February 2020, MDPI AG,
DOI: 10.3390/genes11030268.
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