What is it about?
Our study aimed to assess whether the CHIT1 circulating activity, as a macrophage activation indicator, reflects the change of the adiposity level and the insulin resistance (IR) in children with obesity
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Why is it important?
Human chitotriosidase has the potential to be a valuable measure of the progression of subclinical inflammation in children with obesity. Subclinical inflammation, as expressed by the circulating CHIT1 activity, progresses independently of the abdominal adiposity, as measured by the clinical indicators, and is associated with a change in insulin resistance.
Perspectives
In the clinical setting, chitotriosidase might help in detecting obese children with a high risk of metabolic syndrome in need of a closer follow-up intervention
PhD, MD racataianu nicoleta
UMF Iuliu Hatieganu Cluj-Napoca Romania
Read the Original
This page is a summary of: Exploratory Longitudinal Analysis of the Circulating CHIT1 Activity in Pediatric Patients with Obesity, Children, January 2023, MDPI AG,
DOI: 10.3390/children10010124.
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