What is it about?
We studied 115 healthy, unvaccinated mother-newborn pairs in Pakistan. SARS-CoV-2 anti-RBD IgG antibodies were detected in 76.5% of mothers and 72.2% of cord-blood samples. Maternal antibodies crossed the placenta efficiently, with a transfer ratio of 0.83, and blood counts did not differ significantly by antibody status.
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Why is it important?
Maternal antibodies may provide newborns with temporary protection during early life. Understanding natural antibody transfer can inform research on maternal infection, vaccination timing and protection of infants who are too young for vaccination.
Perspectives
From my perspective, this work matters because Maternal antibodies may provide newborns with temporary protection during early life. I hope the findings support further research and informed, evidence-based decisions.
Yasar Yousafzai
Khyber Medical University
Read the Original
This page is a summary of: Transplacental Transfer of SARS-CoV-2 Receptor-Binding Domain IgG Antibodies from Mothers to Neonates in a Cohort of Pakistani Unvaccinated Mothers, Biomedicines, June 2023, MDPI AG,
DOI: 10.3390/biomedicines11061651.
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