What is it about?
Structural and computational studies of glucoimidazole and mannoimidazole binding to a beta-glucosidase, which prefers glucosides and binds mannoimidazole very poorly, despite binding tightly to glucoimidazole, the structures of which are only different in the direction of bonds at one position.
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Why is it important?
It helps to understand why certain enzymes prefer to hydrolyze glucosides and other mannosides, which are prevalent in nature, and differ only in the chirality at the 2nd carbon of the monosaccharide. It may also be useful for designing better inhibitors.
Perspectives
This is a follow-up to our previous work on Os7BGlu26 beta-mannosidase, which is closely related to Os3BGlu7 beta-glucosidase, but prefers mannosides over glucosides and can effectively bind mannoimidazole.
Professor James R Ketudat Cairns
Suranaree University of Technology
Read the Original
This page is a summary of: Structural Basis of Specific Glucoimidazole and Mannoimidazole Binding by Os3BGlu7, Biomolecules, June 2020, MDPI AG,
DOI: 10.3390/biom10060907.
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