Two-Component FAD-Dependent Monooxygenases: Current Knowledge and Biotechnological Opportunities

Thomas Heine, Willem van Berkel, George Gassner, Karl-Heinz van Pée, Dirk Tischler
  • Biology, August 2018, MDPI AG
  • DOI: 10.3390/biology7030042

Two-component FAD-dependent monooxygenases

What is it about?

Two-component FAD-dependent monooxygenases create valuable compounds that are of high interest for the chemical, pharmaceutical, and agrochemical industries. In this review we describe the mode of action of these enzymes and their biotechnological relevance.

Why is it important?

Two-component FAD-dependent monooxygenases catalyze hydroxylation, epoxidation, and halogenation reactions and are physiologically involved in amino acid metabolism, mineralization of aromatic compounds, and biosynthesis of secondary metabolites.


Professor Willem J.H. van Berkel
Wageningen University

More and more representatives of two-component FAD-dependent monooxygenases are being discovered and their characterisation will result in the identification of novel physiological roles, functional properties, and a variety of biocatalytic opportunities.

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The following have contributed to this page: Dr Dirk Tischler and Professor Willem J.H. van Berkel