What is it about?
Extensive burns result in local wound response and distant-organ injury (DOI) caused by oxidative stress and inflammation. Melatonin (MT) shows promise in alleviating oxidative stress and inflammation, but its role in thermal injury is largely unexplored. The present systematic review and meta-analysis were designed to assess the effects of MT on oxidative-stress and inflammatory markers against severe burn-induced DOI.
Featured Image
Photo by Austrian National Library on Unsplash
Why is it important?
Meta-analysis indicates that severe burn followed by immediate MT (10 mg/kg) intervention shows significant beneficial effects after 24-h against DOI by regulating oxidative-stress and the inflammatory response.
Perspectives
Melatonin may reduce the adverse effects of antioxidants and/or other drugs that currently used to treat burn patients, consequently will increase their efficacy.
Dewan Md. Sumsuzzman
Inje University
Read the Original
This page is a summary of: Protective Effects of Melatonin against Severe Burn-Induced Distant Organ Injury: A Systematic Review and Meta-Analysis of Experimental Studies, Antioxidants, November 2020, MDPI AG,
DOI: 10.3390/antiox9121196.
You can read the full text:
Contributors
The following have contributed to this page
