What is it about?
Hawthorn (HAW) herbal preparation appears to function via modulation of oxidative stress, reduction of inflammation and inhibition of HSC activation. Accordingly, the present findings introduce HAW as a novel drug candidate for treating liver fibrosis. However, these observations require additional experiments for verification.
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Why is it important?
The current study was conducted to evaluate antifibrotic effect Hawthorn herbal treatment against CCl4-induced liver fibrosis. HAW not only decreased liver injury, and recovered liver function, but also reduced ECM deposition
Perspectives
HAW appears to function via modulation of oxidative stress, reduction of inflammation and inhibition of HSC activation. Accordingly, the present findings introduce HAW as a novel drug candidate for treating liver fibrosis. However, these observations require additional experiments for verification. Further studies are expected to elucidate the pharmacodynamics and pharmacokinetics of this herbal medication. In addition, whether HAW’s beneficial effects can be manifested in humans awaits future clinical trials.
Dr Alaaeldin A Hamza
National Organization for Drug Control and Research
Read the Original
This page is a summary of: Hawthorn Herbal Preparation from Crataegus oxyacantha Attenuates In Vivo Carbon Tetrachloride -Induced Hepatic Fibrosis via Modulating Oxidative Stress and Inflammation, Antioxidants, November 2020, MDPI AG,
DOI: 10.3390/antiox9121173.
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