What is it about?
Piceatannol (PIC, or 3,5,3',4'-tetrahydroxystilbene, Figure 1) is a naturally occurring polyphenolic compound and exists in fruits and herbal plants. In terms of structure, piceatannol has four hydroxyl groups and one extra hydroxyl group in comparison with resveratrol.
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Why is it important?
Piceatannol is a potential ingredient in the development of nutraceuticals or functional foods or can serve as a lead compound for the treatment of an unmet medical need in neurodegen-erative disorders.
Perspectives
The human equivalent concentration of the piceatannol treatment dose (50 mg/kg) for scopolamine-induced ICR mice was calculated to be 4.054 mg/kg, and an adult weighing 60 kg is expected to receive similar beneficial effects by taking about 250 mg of PIC per day based on the literature of 【Reagan-Shaw et al., FASEB J. 2007, 22, 659-661】. However, further investigations in clinical trials are needed.
Professor Wen-Chi Hou
Taipei Medical University
Read the Original
This page is a summary of: Inhibition of Acetylcholinesterase and Amyloid-β Aggregation by Piceatannol and Analogs: Assessing In Vitro and In Vivo Impact on a Murine Model of Scopolamine-Induced Memory Impairment, Antioxidants, June 2023, MDPI AG,
DOI: 10.3390/antiox12071362.
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