The cell Line SH-SY5Y is resistant to infection by Ebola virus and other filoviruses
What is it about?
The highly pathogenic Ebola virus (EBOV), a member of the family Filoviridae, can enter a diverse range of cell types and only lymphocytes are known to be non-susceptible. This study shows that the cell line SH-SY5Y is resistant to entry of EBOV and other filoviruses and that entry can be restored upon expression of diverse attachment factors.
Why is it important?
This study identifies the first adherent , non-lymphocyte human cell line resistant to filovirus infection. Moreover, it provides the first evidence that the attachment step can limit filovirus entry into target cells.
The following have contributed to this page: Professor Stefan Pöhlmann