What is it about?
Investigation of metabolic profile of Mansoa hirsuta. Pharmacophore, and molecular docking analysis in order to better understand the potential mechanism of the antioxidant activity of its major metabolites.
Featured Image
Photo by Alexandre Caron on Unsplash
Why is it important?
Our findings demonstrate the antioxidant capacity of different parts of the plant. Molecular docking analysis is performed on the two triterpenes to determine whether the compounds bound to the important receptors which are connected to antioxidant mechanisms. These compounds give good binding potentials associated with antioxidant activity. From these results, a pharmacophore model is proposed to help guide future studies. Additionally, the proposed pharmacophore model should be used as a future guide for selecting and designing triterpenes as antioxidants.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long-standing collaborations. This research also leads to the antioxidant activity of Mansoa hirsute and ultimately to greater involvement in computational studies such as molecular docking as well as pharmacophore modeling as a future guide for selecting and designing triterpenes as antioxidants.
GAGAN PREET
University of Aberdeen
Read the Original
This page is a summary of: The Free Radical Scavenging Property of the Leaves, Branches, and Roots of Mansoa hirsuta DC: In Vitro Assessment, 3D Pharmacophore, and Molecular Docking Study, Molecules, September 2022, MDPI AG,
DOI: 10.3390/molecules27186016.
You can read the full text:
Contributors
The following have contributed to this page
