Liposomal Drug Delivery Systems and Anticancer Drugs

Temidayo Olusanya, Rita Haj Ahmad, Daniel Ibegbu, James Smith, Amal Elkordy
  • Molecules, April 2018, MDPI AG
  • DOI: 10.3390/molecules23040907

Targeting cancer cells using nanoparticles

What is it about?

This open-access review paper describes various types of liposome nanoparticles that have been used to encapsulate chemotherapy drugs, enabling them to target cancer cells.

Why is it important?

Cancer is a life-threatening disease contributing to ~3.4 million deaths annually worldwide. The main clinical failure of chemotherapy drugs is that they are administered systemically (all around the body) and a low concentration is delivered to the target cancer site. Increasing the dose only exposes normal cells to the cytotoxic drug causing harmful side effects. Encapsulation of anti-cancer drugs within nanoparticles is a powerful method of making targeted delivery of the therapeutic agent to the cancer cells. Liposomes are a type of nanoparticle that are particularly easy to produce, to functionalise and can be made small enough to take drugs across the blood-brain-barrier, which prevents many potential drugs from reaching the brain to treat brain tumours.

Perspectives

Dr James R Smith (Author)
University of Portsmouth

This paper is open access from the Journal webpage.

Read Publication

http://dx.doi.org/10.3390/molecules23040907

The following have contributed to this page: Dr James R Smith