Preparation of Porous Scaffolds from Silk Fibroin Extracted from the Silk Gland of Bombyx mori (B. mori)

Mingying Yang, Yajun Shuai, Wen He, Sijia Min, Liangjun Zhu
  • International Journal of Molecular Sciences, June 2012, MDPI AG
  • DOI: 10.3390/ijms13067762

Extract natrual proteins, Preparation of 3D Scaffolds, Potential application in tissue engineering

What is it about?

The silk spun from domestic silkworm Bombyx mori (B. mori) has been used commercially for biomedical sutures for several decades, and in textile production for at least 2500 years. The silk from B. mori consists primarily of two protein components: Fibroin and sericin. We develop a simple and ecofriendly method to prepare porous silk scaffolds, by extracted silk fibroin from the silk gland of 7-day-old fifth instar larvae. The morphology, porosity, mechanical properties and in vitrobiological activity of porous scaffolds are discussed in this study.

Why is it important?

The prepared porous scaffolds has impressive compressive strength and high cell adhesion and biocompatibility. Therefore, the porous scaffolds prepared in this study show promise for potential application in tissue engineering.

Perspectives

Yajun Shuai (Author)

This research was my first project during my postgraduate career. Since doing this project, I like the research direction in the field of biomaterials. At the same time, some new findings in this paper will also provide some references for the future application of biomacromolecules in tissue engineering.

The following have contributed to this page: Yajun Shuai