What is it about?
This paper reveals that the theory of multistep oncogenic mutation leading to cancer development is highly questionable. Healthy lifestyle factors upregulate estrogen signaling and may reduce the cancer risk even in patients with germline oncogenic mutations. Conversely, bad habits and lifestyle factors may downregulate estrogen signaling and increase cancer risk even in patients without genetic susceptibility.
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Why is it important?
There is no need of oncogenic mutation, impaired estrogen signaling leads to genomic instability and increased cancer risk. Healthy lifestyle may upregulate estrogen signaling helping healthy cells, tumor cells and the whole body in their fight against deregulation, even in genetically susceptible patients.
Perspectives
Carcer maybe prevented and cured by the upregulation of all genomic processes instead of their inhibition and blockade.
professor Zsuzsanna Suba
National Institute of Oncology Budapest
Read the Original
This page is a summary of: Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling, Cancers, December 2025, MDPI AG,
DOI: 10.3390/cancers18010078.
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