What is it about?

Since tumor initiation and growth may be attributed to a patient’s genomic instability and damage, genotoxic medications are inappropriate as they cause additional genomic damage in both patients and their cancers. . Tumor cells are not enemies to be killed, but rather they are ill human cells which have the remnants of same genome stabilizer pathways like healthy cells. Within tumors, there is a combat for the improvement of their genomic defects. Moreover, tumors ask for help in their kamikaze action by recruiting immune competent cells into their environment.

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Why is it important?

Genomic instability caused by either germline mutation or harmful exogenous influences induces emergency responses in healthy cells via somatic mutations driving upregulation of estrogen signal and DNA stabilization. The dynamic communication between the tumor and its microenvironment is a marvelous collaboration among molecular players fighting for genomic repair and apoptosis of tumor by means of their genomic plasticity. We should learn by watching the genome repairing activities within tumors, in the peritumoral region and in the whole body, and may follow them with supportive care.


Successful cancer therapy does not remain a dream to be realized in the far future, but we should set about a cancer cure without delay. This work is invited for nomination to Distingwished Cancer Therapy Innovation Award.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

Read the Original

This page is a summary of: DNA Damage Responses in Tumors Are Not Proliferative Stimuli, but Rather They Are DNA Repair Actions Requiring Supportive Medical Care, Cancers, April 2024, MDPI AG,
DOI: 10.3390/cancers16081573.
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