What is it about?

In women, estrogen predominance seems to be protective against DNA damage and development of tumors as compared with men. Failure of high dose synthetic estrogen and antiestrogen treatment of breast cancer revealed that endocrine disruption is not an effective means to defeat breast cancer. Clarifying the role of estrogen signal in genomic stability and human health seemes to be a key to cancer research leading to great progress in cancer therapy.

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Why is it important?

Recognition of the molecular mechanisms of estrogen receptor deregulation via synthetic estrogen and antiestrogen treatment, helped to reveal the omnipotent curing capacity of endogenous estrogens via balanced liganded and unliganded activation of estrgen receptors.

Perspectives

Recognition of the principal gene regulative and gene editing capacities of endogenous estrogens may thoroughly repurpose the genomic and proteomic therapy of cancer and all human diseases.

professor Zsuzsanna Suba
National Institute of Oncology Budapest

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This page is a summary of: Rosetta Stone for Cancer Cure: Comparison of the Anticancer Capacity of Endogenous Estrogens, Synthetic Estrogens and Antiestrogens, Oncology Reviews, April 2023, Frontiers,
DOI: 10.3389/or.2023.10708.
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