What is it about?
Improving mortality and morbidity after major surgery by bolstering the patient's response to the stress of surgery.
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Why is it important?
Surgical trauma is often referred to as the “neglected step-child” of global health in terms of patient numbers, mortality, morbidity, and costs. A staggering 234 million major surgeries are performed every year, and depending upon country and institution, up to 4% of patients will die before leaving hospital, up to 15% will have serious post-operative morbidity, and 5–15% will be readmitted within 30 days. These percentages equate to around 1000 deaths and 4000 major complications every hour, and it has been estimated that 50% may be preventable.
Perspectives
We have developed a low volume ALM 'drip' therapy that bolster's the body's response against the trauma of surgery. The idea is to begin the drip after anesthesia but before the first incision. In different trauma states, the drug appears to work by improving CNS control of cardiovascular-endothelium function, correcting coagulopathy and reducing inflammation. The goal is to reduce mortality and morbidity after major surgery.
Dr Geoffrey P Dobson
James Cook University
Read the Original
This page is a summary of: Addressing the Global Burden of Trauma in Major Surgery, Frontiers in Surgery, September 2015, Frontiers,
DOI: 10.3389/fsurg.2015.00043.
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