Neuroprotective Effects of Probenecid on Spinal Cord Injury

What is it about?

Probenecid, an inhibitor of the Pannexin-1 channel, can inhibit the activation of inflammasomes. Our studies indicated that probenecid can alleviate inflammation by blocking Pannexin-1 channels to inhibit the expression of caspase-1 and IL-1β and exerts neuroprotective effects in rats with SCI.

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Why is it important?

Probenecid can increase the survival of motor neurons, which resulted in tissue repair and improved locomotor function in the injured spinal cord.