What is it about?
Antimicrobial peptides are promising compounds since they can kill multi-drug resistant bacteria. It is also shown that these peptides have multiple modes of action. BioSAXS can follow the molecular changes in bacteria after treatment with antimicrobial compounds. Here we have shown that two peptides induce similar changes in gram-positive and gram-negative bacteria, indicating a similar mechanism of action for both classes.
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Why is it important?
Selecting antimicrobial peptides by their modes of action is a more promising approach for drug development than just by their power of antimicrobial activity. Otherwise, cross-resistance against novel peptides can occur or develop easily. With this new method, a high-throughput screening to classify according to modes of action is possible. This can accelerate the development of various peptides as drugs against multi-drug resistant bacteria.
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This page is a summary of: BioSAXS Measurements Reveal That Two Antimicrobial Peptides Induce Similar Molecular Changes in Gram-Negative and Gram-Positive Bacteria, Frontiers in Pharmacology, September 2019, Frontiers, DOI: 10.3389/fphar.2019.01127.
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