What is it about?

Networks are present in many aspects of our lives, and networks in neuroscience have recently gained much attention leading to novel representations of brain connectivity. The integration of neuroimaging characteristics and genetics data allows a better understanding of the effects of the gene expression on brain structural and functional connections. The current work uses whole-brain tractography in a longitudinal setting, and by measuring the brain structural connectivity changes studies the neurodegeneration of Alzheimer's disease. This is accomplished by examining the effect of targeted genetic risk factors on the most common local and global brain connectivity measures.

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Why is it important?

We are connecting changes in the brain to genes Our findings provide insights into the complex longitudinal interplay between genetics and brain characteristics and highlight the role of Alzheimer's genetic risk factors in the estimation of regional brain connectivity alterations.


Local impact of Alzheimer's disease can suggest personalized treatments

Alessandro Crimi

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This page is a summary of: Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease, Frontiers in Human Neuroscience, December 2021, Frontiers, DOI: 10.3389/fnhum.2021.761424.
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