DOES A SINGLE DOSE OF VITAMIN D3 IMPROVE GLYCEMIC CONTROL IN TYPE 2 DIABETES MELLITUS

What is it about?

According to recent studies, vitamin D deficiency has been correlated with progress in type 2 Diabetes and Metabolic Syndrome. This randomized double-blind clinical trial was conducted with 50 diabetic patients, who visit The National Diabetes Center, in two groups. The intervention group was implied by one single dose of 300,000 IU cholecalciferol ampule and the placebo group included oral paraffin. After recording demographic and anthropometric factors, fasting blood samples was taken for measurement of blood glucose, 25-hydroxyvitamin D3 (25-OHD3), insulin, HbA1c in two times; before the study and after eight weeks. Two groups had similar baseline characteristics (each group = 25 subjects). No statistically significant differences in the anthropometric parameters between case and control groups were observed. Vitamin D supplementation significantly increased serum vitamin D level (P = 0.0002) and a highly significant decrease (P = 0.0003) in the level of fasting blood glucose. There is no significant difference in the HbA1c ratio between both groups, but there is significantly decreasing after treatment with cholecalciferol (P=0.012). This result shows highly significance decrease (P ≤ 0.0001) in the concentration of cholesterol between both groups at post-intervention and after treatment with cholecalciferol. Also, a highly significant decrease in the level of LDL. HDL shows a highly significant increase between the two groups after supplementation with vitamin D. Triglyceride and VLDL levels significantly decreasing after treatment with cholecalciferol, respectively (P = 0.0185), (P = 0.0192). However, there are no significant differences in the level of TG (P = 0.5698) and VLDL (P = 0.4552) between the groups at post-intervention. There was not any significant difference in the level of urea and serum creatinine between two groups at the end of the intervention. Our results represented that, the single dose of vitamin D Supplementation 300,000 IU for 8 weeks may be effective by improving HbA1C and lipid profile in Iraqi patients with type 2 diabetes.

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Photo by freestocks on Unsplash

Photo by freestocks on Unsplash

Why is it important?

This study was designed to investigate the effect of a single dose of vitamin D on glucose and lipid profiles, blood pressure and biomarkers of kidney in Iraqi patients with type 2 diabetes.

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