What is it about?
Renin distal enhancer plays a crucial role in regulatingrenin gene (REN) expression. REN C-5312T enhancer polymorphism increased enhancer activity . REN C-5434T was also identified which supposed to part of enhancer region. This study represents the genetic investigation of apossible contribution of REN C-5312T and C-5434T polymorphism to serum angiotensin I in response to angiotensin II receptor blockers (ARB).
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Why is it important?
Our finding show that in hypertensive ARB treated patient , REN C-5312T but not REN C-5434T , polymorphism resulted in increased mRNA renin level as consequence of higher enhancer activity not only at the baseline but also after 5 months ARB treatment
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This page is a summary of: REN C-5312T, but not C-5434T, correlates to increase serum angiotensin I level in angiotensin II receptor blockers-treated hypertensive patients, Bangladesh Journal of Pharmacology, May 2016, Bangladesh Journals Online (BanglaJOL),
DOI: 10.3329/bjp.v11i2.25818.
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