Safinamide effects on motor fluctuations and cardinal symptoms in Parkinsonian fluctuating patients

What is it about?

This is a post-hoc analysis of the pooled data of two pivotal trials on the effects of safinamide on motor fluctuations and on cardinal symptoms of PD in different subgroups of fluctuating patients, treated with levodopa alone or levodopa + other dopaminergic drugs, or with initial wearing-off.

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Why is it important?

The findings of this post-hoc analysis suggest that safinamide can improve motor fluctuations and cardinal smptoms of PD even in patients with optimized dopaminergic therapy. Moreover, safinamide could be used either as first add-on to levodopa or as add-on in patients treated with levodopa and other dopaminergic therapies.