What is it about?
Cytokines are glycoproteins or immunomodulatory proteins generated by a wide range of cells and have intricate functions. They can positively or negatively influence a cell’s ability to divide, develop, differentiate, migrate, die, and produce cytokines and other cell products. The immune response’s equilibrium depends critically on a functioning cytokine network, and disruption of this network might result in an aberrant immunological response.
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Why is it important?
Overall, our study contributes to the growing body of literature on the genetic basis of TB susceptibility and underscores the importance of robust meta-analyses in elucidating the role of genetic factors in infectious diseases.
Perspectives
TB remains one of the most pressing global health challenges, particularly in developing countries, where host genetic factors play a significant role in determining disease susceptibility and progression. Among the cytokines that regulate the host immune response to Mycobacterium tuberculosis, Interleukin-10 (IL-10) is a key anti-inflammatory mediator known to suppress Th1-type responses and inhibit the activation of macrophage. Variations or polymorphisms in the IL-10 gene, especially within promoter regions, can influence the level of IL-10 expression, thereby modulating the host’s immune defense against TB. Understanding the genetic diversity in IL-10, such as the commonly studied -1082A/G, -819C/T, and -592C/A polymorphisms, may offer valuable insights into individual and population-level vulnerability to TB. Identifying these genetic risk factors is critical not only for advancing the understanding of TB pathogenesis but also for developing personalized approaches to prevention, diagnosis, and treatment strategies. This study aims to explore the association between IL-10 gene polymorphisms and TB susceptibility, thereby contributing to the growing field of host genetic biomarkers in infectious diseases.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Meta-analysis of interleukin-10 gene polymorphisms and tuberculosis susceptibility: Insights from recent studies, Human Antibodies, November 2024, SAGE Publications,
DOI: 10.3233/hab-240024.
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