What is it about?

Prevalent deposition of synuclein aggregates in autonomic cutaneous fibers differentiate Parkinson’s disease from multiple system atrophy in early stage of disease. A higher occurence of synuclein deposits is found in patients with more preserved cutaneous innervation.

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Why is it important?

Early differential diagnosis of parkinsonisms is important to reduce the diagnostic delay and to adopt since the onset, correct therapeutic strategies. This leads to a reduction of disease-specific complications and overall to a better management of patients.


I believe that the analysis of nerves in a readily available tissue like the skin, is a suitable tool to identify biomarkers that can be useful for diagnosis, prognosis and follow-up of patients with parkinsonism. Such biomarkers can be useful to better stratify patients for future clinical trials to assess the efficacy of new disease-specific drugs.

Maria Nolano
Universita degli Studi di Napoli Federico II

Read the Original

This page is a summary of: Phosphorylated α-Synuclein Deposits in Cutaneous Nerves of Early Parkinsonism, Journal of Parkinson s Disease, December 2022, IOS Press,
DOI: 10.3233/jpd-223421.
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