Comparing in-person and remote cognitive scores related to Alzheimer's disease with brain imaging

What is it about?

The original preclinical Alzheimer's cognitive composite (PACC) was developed for in-person administration to capture subtle cognitive decline. We created a remote-friendly cognitive composite for identifying cognitive differences in older adults. We showed that this new test, administered via phone or video, is as reliable as in-person tests and correlates with key brain health markers, making it effective for remote participant evaluations.

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Why is it important?

Our study developed a telehealth-compatible cognitive composite (tPACC) to detect subtle cognitive differences in Alzheimer's. We found that tPACC, whether administered in-person or remotely, aligns well with the original composite and is linked to key imaging biomarkers, supporting its reliability for remote assessments.