What is it about?

we aimed to figure out a strategy to reduce sGC levels by microRNA (miRNA) intervention. Bioinformatical studies were then performed to predict sGC-targeting miRNAs; additionally, an assay of dual luciferase reporter was used for evaluating the functional binding of miRNAs to sGC. Among all sGC-targeting miRNAs, in particularly we found that miR-142-5p markedly inhibited sGC protein translation by pairing to the 3'-UTR of the sGC mRNA. Orthotopic injection of adeno-associated virus carrying miR-142-5p significantly decreased sGC and sGMP levels, resulting in reduction of the neuropathic pain in rats with the left hind leg sciatic nerve injured in the tibia and peroneal branches.

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Why is it important?

The proper evaluation and effective treatment of acute and persistent neuropathic pain (NP) is especially important for nursing home patients with Alzheimer’s disease (AD). The prevalence of AD-associated neuropathic pain appeared to be extremely high in the primary health care system, both in nursing home patients with dementia and without dementia . AD and vascular dementia (VaD) are age-related diseases with a significant increase in prevalence in recent years. In advanced stages of dementia, it is often combined with AD to form mixed dementia (AD-VaD), as the most prevalent in nursing home patients .


It may be interesting to study the interaction of these miRNAs with human homologs in future studies, which may provide a translatable therapeutic strategy to deal with NP in AD and dementia.

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Read the Original

This page is a summary of: Post-Transcriptional Regulation of Soluble Guanylate Cyclase that Governs Neuropathic Pain in Alzheimer’s Disease, Journal of Alzheimer s Disease, October 2019, IOS Press, DOI: 10.3233/jad-190743.
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