Quantitative Susceptibility Mapping of Amyloid-β Aggregates in Alzheimer’s Disease with 7T MR

Solveig Tiepolt, Andreas Schäfer, Michael Rullmann, Elisabeth Roggenhofer, Hermann-Josef Gertz, Matthias L. Schroeter, Marianne Patt, Pierre-Louis Bazin, Thies H. Jochimsen, Robert Turner, Osama Sabri, Henryk Barthel
  • Journal of Alzheimer s Disease, June 2018, IOS Press
  • DOI: 10.3233/jad-180118

QSM with 7T MRI in AD

What is it about?

Post-mortem human Alzheimer’s disease (AD) and healthy control (HC) frontal gray matter (GM) was imaged with 7T MRI which resulted in T1 maps and QSM. Aβ plaque load was determined by histopathology. In vivo, 10 Aβ PET-positive AD patients and 10 Aβ PET-negative HCs underwent 7T MR examination and QSM maps were analyzed. Severity of cognitive deficits was determined by MMSE.

Why is it important?

Post-mortem, the susceptibility of Aβ plaque-containing GM were higher than those of Aβ plaque-free GM. In vivo, only the bilateral globus pallidus showed significantly higher susceptibility in AD patients compared to HCs. The pallidal QSM values were negatively correlated with those of the MMSE.

Perspectives

Solveig Tiepolt (Author)
International University in Germany gGmbH

The post-mortem study revealed significant susceptibility differences between the Aβ plaque-containing and Aβ plaque-free GM, whereas in-vivo only the QSM values of the globus pallidus differed significantly between AD and HC group. The pallidal QSM values correlated with the severity of cognitive deficits. These findings encourage efforts to optimize the 7T-QSM methodology.

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http://dx.doi.org/10.3233/jad-180118

The following have contributed to this page: Solveig Tiepolt