The Alzheimer's protein, Amyloid-β, helps protect our brains from microbes
What is it about?
Amyloid-β is best known as a harmful protein that accumulates in the brain of people with Alzheimer's disease. However, this protein also has important roles as part of the human immune system. A growing body of evidence suggests that amyloid-β can trap and kill invading microbes that could lead to a brain infection.
Why is it important?
Most recent clinical trials for Alzheimer's disease have targeted amyloid-β. https://www.growkudos.com/publications/10.3233%252Fjad-171133These trials suffer from poor effectiveness and often cause side effects, including infections. By considering amyloid-β's important role as an antimicrobial peptide, we may be able to address these problems and create more effective treatments.
The following have contributed to this page: Maya L Gosztyla and Stephen Robinson
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