Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study

Karim Bennys, Audrey Gabelle, Claudine Berr, Delphine De Verbizier, Sandrine Andrieu, Bruno Vellas, Jacques Touchon
  • Journal of Alzheimer s Disease, May 2017, IOS Press
  • DOI: 10.3233/jad-161012


What is it about?

A better knowledge of Alzheimer’s disease (AD) physiopathology highlighted synaptic dysfunction as a primarily pathological process mediated by the toxicity of soluble Aβ oligomers. It’s well known that event-related potential (ERP) method, because particularly accessible to non-invasive study provides a sensitive measure of synaptic dysfunction at early stages of AD. Nowadays, we stress the need for developing a simple noninvasive screening tool for a reliable identification of elderly subjects who display underlying AD lesions at preclinical stage. Findings from our clinical study show that ERP display a good predictive value for the presence of brain amyloid load in elderly subjects at risk to develop AD.

Why is it important?

Our project will bring the possibility of developing a simple screening tool for a “timely diagnosis” that could improve the screening of the patients in clinical trials without invasive explorations.



We propose to incorporate cognitive ERP, which provide powerful and non-invasive tools for studying the brain’s synaptic function into the new criteria for the preclinical stages of AD.

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