Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study

Karim Bennys, Audrey Gabelle, Claudine Berr, Delphine De Verbizier, Sandrine Andrieu, Bruno Vellas, Jacques Touchon
  • Journal of Alzheimer s Disease, May 2017, IOS Press
  • DOI: 10.3233/jad-161012

The ERP MAPT PLUS study

What is it about?

A better knowledge of Alzheimer’s disease (AD) physiopathology highlighted synaptic dysfunction as a primarily pathological process mediated by the toxicity of soluble Aβ oligomers. It’s well known that event-related potential (ERP) method, because particularly accessible to non-invasive study provides a sensitive measure of synaptic dysfunction at early stages of AD. Nowadays, we stress the need for developing a simple noninvasive screening tool for a reliable identification of elderly subjects who display underlying AD lesions at preclinical stage. Findings from our clinical study show that ERP display a good predictive value for the presence of brain amyloid load in elderly subjects at risk to develop AD.

Why is it important?

Our project will bring the possibility of developing a simple screening tool for a “timely diagnosis” that could improve the screening of the patients in clinical trials without invasive explorations.

Perspectives

KARIM BENNYS (Author)

We propose to incorporate cognitive ERP, which provide powerful and non-invasive tools for studying the brain’s synaptic function into the new criteria for the preclinical stages of AD.

The following have contributed to this page: KARIM BENNYS

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