What is it about?
This study describes 13 rare cases of bloodstream infections caused by Alistipes species—a group of anaerobic bacteria typically found in the human gut—at a tertiary hospital in Japan. Using MALDI-TOF mass spectrometry, 16S rRNA gene sequencing, and whole-genome analysis, we identified several Alistipes species, including A. finegoldii, A. putredinis, and A. onderdonkii. We examined patient characteristics, clinical symptoms, antimicrobial treatments, and bacterial resistance profiles.
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Why is it important?
Alistipes is rarely identified in clinical laboratories but can cause true bloodstream infections, particularly in patients with digestive tract conditions or cancer. Because these bacteria can be difficult to detect and may show resistance to common antibiotics, our findings emphasize the need for accurate identification methods and the careful selection of antimicrobial therapy to ensure better outcomes in vulnerable patients.
Perspectives
As diagnostic technologies like MALDI-TOF mass spectrometry and 16S rRNA gene sequencing continue to evolve, rare pathogens such as Alistipes will likely be recognized more often. Raising awareness among clinicians and laboratory professionals is essential. Expanding microbial databases and further investigating resistance mechanisms will enhance our ability to diagnose and treat these infections effectively, especially in aging or immunocompromised populations.
Dr Naoki Watanabe
Kameda Medical Center
Read the Original
This page is a summary of: Alistipes Bacteremia in Older Patients with Digestive and Cancer Comorbidities, Japan, 2016–2023, Emerging Infectious Diseases, April 2025, Centers for Disease Control and Prevention (CDC),
DOI: 10.3201/eid3104.241284.
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